Development of an Old Reagent for the Reduction of Solid-Supported Alkenes

By Duncan Wardrop

University of Illinois at Chicago

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This module allows students to carry out a solid phase organic synthesis of the natural products zingerone and raspberry ketone and to use the synthetic routes to these compounds as a vehicle with which to evaluate reagents for the efficient reduction of immobilized alkenes. Students will learn and perform several organic synthesis reactions and tests. The lab techniques employed in this module include Volhard titration, thin layer chromatography (TLC), and infrared spectroscopy (IR). The ultimate goal of this module is to explore possible alternatives for a reagent within the synthesis scheme and determine their effectiveness.